Table 1:
Characteristics of cardiac surgery patients randomized to a mean arterial blood pressure of either 40–50 mmHg (low) or 70–80 mmHg (high)
| Low MAP allocation (n = 98) | High MAP allocation (n = 95) | |
|---|---|---|
| Demographics | ||
| Age (years), mean ± SD | 65 ± 11 | 69 ± 8.5 |
| Male gender, n (%) | 92 (94) | 81 (85) |
| Actively working, n (%) | 61 (62) | 69 (73) |
| Medical history, n (%) | ||
| Recent myocardial infarction | 31 (32) | 23 (24) |
| Hypertension | 82 (84) | 84 (88) |
| Diabetes mellitus | 24 (24) | 24 (25) |
| Current smoker | 18 (18) | 15 (16) |
| Current alcohol abuse | 7 (7.1) | 7 (7.4) |
| Symptoms, n (%) | ||
| CCS score above 1 | 63 (64) | 46 (48) |
| NYHA class, n (%) | ||
| I | 32 (33) | 20 (21) |
| II | 34 (35) | 44 (46) |
| III | 28 (29) | 25 (26) |
| IV | 4 (4.1) | 6 (6.3) |
| Objective findings | ||
| BMI (kg/m2), mean ± SD | 27 ± 3.8 | 27 ± 3.9 |
| Heart rate (bpm), mean ± SD | 67 ± 14 | 69 ± 11 |
| Left ventricular ejection fraction, median (IQR) | 55 (45–60) | 55 (45–60) |
| P-creatinine (µmol/l), mean ± SD | 92 ± 28 | 88 ± 17 |
| EuroSCORE II (%), median (IQR) | 1.6 (0.97–2.9) | 2.0 (1.3–3.1) |
| Surgical procedure | ||
| CABG, n (%) | 67 (68) | 71 (75) |
| No. grafts, median (IQR) | 2 (0 - 3) | 2 (0 - 3) |
| AVR, n (%) | 27 (28) | 29 (31) |
| MVR, n (%) | 4 (4.1) | 6 (6.3) |
| MAP during bypass (mmHg), mean ± SD | 45 ± 4.7 | 67 ± 4.7 |
| Surgery time (min), mean ± SD | 185 ± 49 | 190 ± 57 |
| CPB time (min), mean ± SD | 94 ± 32 | 103 ± 72 |
| Cross-clamp time (min), mean ± SD | 63 ± 27 | 64 ± 29 |
AVR: aortic valve replacement; CABG: coronary artery bypass grafting; CPB: cardiopulmonary bypass; CCS: Canadian Cardiovascular Society; IQR: interquartile range; MAP: mean arterial pressure; MVR: Mitral valve replacement; NYHA: New York Heart Association; SD: standard deviation.