Table 3:

Type III tests of fixed effects from constrained linear mixed models for each biomarker measured in cardiac surgery patients randomized to a mean arterial blood pressure of either 40–50 mmHg (low) or 70–80 mmHg (high)

Covariate	Neuron-specific enolase	Tau	Neurofilament light	Glial fibrillary acidic protein
	P-value	P-value	P-value	P-value
MAP allocation group	0.86	0.02	0.68	0.20
Age (years)	0.44	0.37	<0.0001	<0.0001
Sex	0.63	0.0005	0.01	0.04
Type of surgery (CABG versus AVR)	0.27	0.27	0.11	0.26
MAP allocation group-by-time interaction	0.14	0.47	0.22	0.14

AVR: aortic valve replacement; CABG: coronary artery bypass grafting; MAP: mean arterial pressure.