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. 2022 Feb 18;20(2):e3001569. doi: 10.1371/journal.pbio.3001569

Fig 7. Env sites with positive net site differential selection (diffsel) are clustered at the trimer apex.

Fig 7

Average net site diffsel values across Env for (A) +XBP1s (B) +XBP1s/+ATF6, and (C) +ATF6, normalized to the basal endoplasmic reticulum proteostasis environment, are mapped onto Env trimer crystal structure (PDB ID: 5FYK) [73]. One monomer is colored using net site diffsel as the color spectrum; negative net site diffsel residues are colored in blue, and positive net site diffsel residues are colored in red. The remainder of the Env trimer is colored in grey. Diffsel values are provided at https://github.com/yoon-jimin/2021_HIV_Env_DMS.