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Susceptibility of SFO-1 to β-lactamase inhibitors
| Enzyme | Bush type | IC50 (μg/ml)a
|
|
|---|---|---|---|
| Clavulanic acid | Imipenem | ||
| SFO-1 | 2e | 0.1 | 0.35 |
| FEC-1 | 2e | 0.0022 | 0.13 |
| Chromosomal β-lactamase of P. vulgaris | 2e | 0.6 | 0.62 |
| TEM-1 | 2b | 1.0 | 14 |
| Chromosomal β-lactamase of E. cloacae | 1 | 12 | 0.24 |
| Chromosomal β-lactamase of E. coli | 1 | 7.8 | 1.4 |
IC50, concentration that inhibits 50% of activity after 10 min of incubation at 37°C; nitrocefin was used as the substrate.
