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. 2022 Feb 23;13:833013. doi: 10.3389/fgene.2022.833013

TABLE 2.

Correlation analysis between GNG7 and relate genes and markers of immune infiltration cells in TIMER.

Description Gene markers COAD READ LIHC
None Purity None Purity None Purity
Cor P Cor P Cor P Cor P Cor P Cor P
CD8+ T cell CD8A 0.361 *** 0.238 *** 0.425 *** 0.33 *** 0.01 0.849 0.063 0.243
CD8B 0.207 *** 0.131 ** 0.182 * 0.158 0.0638 −0.046 0.38 −0.008 0.877
T cell (general) CD3D 0.362 *** 0.229 *** 0.332 *** 0.215 * −0.135 ** −0.105 0.051
CD3E 0.459 *** 0.348 *** 0.454 *** 0.366 *** −0.034 0.516 0.011 0.839
CD2 0.418 *** 0.292 *** 0.412 *** 0.307 *** −0.034 0.51 0.007 0.903
B cell CD19 0.499 *** 0.428 *** 0.36 *** 0.323 *** 0.022 0.669 0.043 0.427
CD79A 0.579 *** 0.505 *** 0.448 *** 0.355 *** 0.02 0.708 0.058 0.283
Monocyte CD86 0.435 *** 0.294 *** 0.424 *** 0.339 *** −0.059 0.253 −0.035 0.522
CD115(CSF1R) 0.517 *** 0.401 *** 0.568 *** 0.532 *** 0.027 0.599 0.054 0.319
TAM CCL2 0.407 *** 0.294 *** 0.493 *** 0.414 *** 0.082 0.114 0.127 *
CD68 0.338 *** 0.219 *** 0.445 *** 0.424 *** −0.094 0.071 −0.067 0.216
IL10 0.328 *** 0.226 *** 0.256 *** 0.193 * −0.107 * −0.101 0.06
M1 Macrophage INOS(NOS2) 0.002 0.961 −0.047 0.346 0.025 0.751 0.046 0.592 0.161 ** 0.158 **
IRF5 0.26 *** 0.233 *** 0.2 * 0.209 * 0.019 0.709 0.01 0.859
COX2(PTGS2) 0.193 *** 0.134 ** 0.2 ** 0.107 0.208 0.02 0.704 0.047 0.384
M2 Macrophage CD163 0.455 *** 0.33 *** 0.508 *** 0.435 *** 0.04 0.44 0.069 0.198
VSIG4 0.427 *** 0.304 *** 0.45 *** 0.375 *** 0.004 0.937 0.034 0.533
MS4A4A 0.414 *** 0.279 *** 0.494 *** 0.408 *** 0.025 0.636 0.066 0.224
Neutrophils CD66b (CEACAM8) −0.117 * −0.072 0.145 −0.148 0.0563 −0.072 0.399 −0.068 0.194 −0.06 0.266
CD11b (ITGAM) 0.427 *** 0.322 *** 0.482 *** 0.392 *** −0.07 0.176 −0.084 0.117
CCR7 0.495 *** 0.399 *** 0.365 *** 0.317 *** 0.082 0.114 0.118 *
Natural killer cell KIR2DL1 0.206 *** 0.134 ** 0.141 0.0707 0.077 0.365 0.03 0.568 0.031 0.569
KIR2DL3 0.143 ** 0.038 0.443 0.198 * 0.144 0.0905 0.118 * 0.141 **
KIR2DL4 0.185 *** 0.079 0.114 0.196 * 0.091 0.287 0.006 0.905 0.029 0.592
KIR3DL1 0.168 *** 0.053 0.290 0.148 0.0574 0.064 0.452 0.16 ** 0.183 ***
KIR3DL2 0.26 *** 0.172 *** 0.304 *** 0.232 ** 0.074 0.157 0.125 *
KIR3DL3 0.069 0.138 0.018 0.713 0.022 0.78 0.012 0.893 0.003 0.954 0.009 0.869
KIR2DS4 0.137 ** 0.082 0.097 0.123 0.114 0.057 0.502 0.128 * 0.139 **
Dendritic cell HLA−DPB1 0.44 *** 0.298 *** 0.453 *** 0.372 *** 0.053 0.306 0.087 0.105
HLA−DQB1 0.308 *** 0.181 *** 0.18 * 0.09 0.29 −0.039 0.449 −0.011 0.834
HLA−DRA 0.355 *** 0.204 *** 0.366 *** 0.244 ** 0.034 0.516 0.064 0.239
HLA−DPA1 0.424 *** 0.283 *** 0.456 *** 0.36 *** 0.058 0.267 0.089 0.101
BDCA−1(CD1C) 0.466 *** 0.381 *** 0.538 *** 0.468 *** 0.018 0.726 0.034 0.534
BDCA−4(NRP1) 0.446 *** 0.323 *** 0.571 *** 0.505 *** 0.139 ** 0.152 **
CD11c (ITGAX) 0.445 *** 0.315 *** 0.456 *** 0.385 *** −0.138 ** −0.143 **
Th1 T−bet (TBX21) 0.374 *** 0.261 *** 0.435 *** 0.367 *** 0.063 0.229 0.092 0.088
STAT4 0.417 *** 0.303 *** 0.422 *** 0.334 *** −0.044 0.397 −0.026 0.628
STAT1 0.233 *** 0.122 * 0.259 *** 0.172 * 0.027 0.607 0.043 0.422
IFN−γ (IFNG) 0.126 ** 0.023 0.645 0.148 0.0576 0.04 0.638 0.002 0.964 0.034 0.525
TNF−α (TNF) 0.229 *** 0.146 ** 0.333 *** 0.272 ** −0.037 0.483 −0.036 0.501
Th2 GATA3 0.488 *** 0.397 *** 0.465 *** 0.399 *** 0.011 0.834 0.043 0.421
STAT6 0.175 *** 0.195 *** 0.224 ** 0.309 *** 0.268 *** 0.259 ***
STAT5A 0.3 *** 0.242 *** 0.163 * 0.159 0.0609 0.171 *** 0.198 ***
IL13 0.155 *** 0.07 0.157 0.105 0.179 −0.021 0.807 −0.025 0.632 −0.056 0.298
Tfh BCL6 0.41 *** 0.311 *** 0.44 *** 0.439 *** 0.043 0.414 0.029 0.591
IL21 0.133 ** 0.079 0.113 0.078 0.32 0.082 0.34 0.032 0.54 0.032 0.559
Th17 STAT3 0.312 *** 0.239 *** 0.398 *** 0.383 *** 0.037 0.477 0.042 0.435
IL17A −0.063 0.179 −0.08 0.106 −0.078 0.316 −0.062 0.472 −0.032 0.541 −0.006 0.91
Treg FOXP3 0.45 *** 0.343 *** 0.479 *** 0.433 *** 0.025 0.638 0.017 0.755
CCR8 0.412 *** 0.317 *** 0.475 *** 0.407 *** −0.053 0.308 −0.05 0.358
STAT5B 0.314 *** 0.32 *** 0.442 *** 0.443 *** 0.225 *** 0.207 ***
TGFβ(TGFB1) 0.504 *** 0.386 *** 0.397 *** 0.301 *** −0.073 0.158 −0.053 0.324
T cell exhaustion PD−1(PDCD1) 0.366 *** 0.26 *** 0.382 *** 0.297 *** −0.067 0.199 −0.031 0.566
CTLA4 0.369 *** 0.253 *** 0.37 *** 0.294 *** −0.152 ** −0.127 *
LAG3 0.351 *** 0.235 *** 0.363 *** 0.303 *** −0.073 0.16 −0.044 0.412
TIM−3(HAVCR2) 0.42 *** 0.281 *** 0.398 *** 0.313 *** −0.093 0.072 −0.078 0.148
GZMB 0.02 0.674 −0.033 0.511 0.134 0.0848 0.077 0.37 0.041 0.433 0.067 0.212

p < 0.05 were considered to be statistically significant (*p < 0.05, **p < 0.01, ***p < 0.001).