TABLE 3.
Correlation analysis between GNG7 and relate genes and markers of immune infiltration cells in GEPIA.
| Description | Gene markers | COAD | READ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Tumor | Normal | Tumor | Normal | ||||||
| R | P | R | P | R | P | R | P | ||
| T cell (general) | CD3E | 0.5 | *** | 0.56 | 0.093 | ||||
| B cell | CD19 | 0.49 | *** | 0.3 | 0.056 | ||||
| CD79A | 0.58 | *** | 0.4 | * | 0.48 | *** | 0.58 | 0.077 | |
| Monocyte | CD115(CSF1R) | 0.52 | *** | 0.35 | 0.027 | 0.68 | *** | 0.6 | 0.069 |
| TAM | CCL2 | 0.61 | *** | 0.71 | 0.021 | ||||
| CD68 | 0.51 | *** | −0.17 | 0.64 | |||||
| M2 Macrophage | CD163 | 0.52 | *** | 0.62 | 0.056 | ||||
| VSIG4 | 0.55 | *** | −0.018 | 0.96 | |||||
| MS4A4A | 0.56 | *** | 0.03 | 0.93 | |||||
| Neutrophils | CD11b (ITGAM) | 0.54 | *** | 0.68 | 0.03 | ||||
| CCR7 | 0.5 | *** | 0.19 | 0.23 | |||||
| Dendritic cell | HLA−DPB1 | 0.6 | *** | 0.079 | 0.83 | ||||
| HLA−DPA1 | 0.57 | *** | 0.44 | 0.21 | |||||
| BDCA−1(CD1C) | 0.52 | *** | 0.2 | 0.2 | 0.55 | *** | 0.63 | 0.05 | |
| BDCA−4(NRP1) | 0.65 | *** | 0.84 | * | |||||
| CD11c (ITGAX) | 0.51 | *** | 0.66 | 0.037 | |||||
| Th1 | T−bet (TBX21) | 0.55 | *** | 0.63 | 0.053 | ||||
| Th2 | GATA3 | 0.55 | *** | 0.23 | 0.15 | 0.55 | *** | 0.63 | 0.05 |
| Tfh | BCL6 | 0.58 | *** | 0.85 | * | ||||
| Th17 | STAT3 | 0.43 | *** | 0.32 | 0.36 | ||||
| Treg | FOXP3 | 0.5 | *** | 0.4 | 0.26 | ||||
| CCR8 | 0.45 | *** | 0.44 | 0.21 | |||||
| STAT5B | 0.43 | ** | 0.94 | ** | |||||
| TGFβ(TGFB1) | 0.49 | *** | 0.61 | *** | |||||
Notes: According to the analysis results in TIMER, all gene markers with correlation coefficients greater than 0.35 after adjustment of tumor purity were verified again in GEPIA, and all the verification results are listed in this table. (*p < 0.01; **p < 0.001; ***p < 0.0001).