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Protein effects of the eyeless mutation. A, RAX polypeptide maps showing octapeptide (OP), homeodomain (HD), RX, and OAR domains, dual start codons, exon junctions (arrowheads), the predicted eyeless protein with Δ5 frameshift mutation and C-terminal nonsense peptide (red). B, Vertebrate RAX homeobox amino acid alignment, showing sequence identities, three critical α-helices for DNA binding, and eyeless HD
