Figure 5.

Effective delivery of single-domain antibody to lung via inhalation

(A) Schematic diagram of n3113v biodistribution in mice by inhalation and intraperitoneal injection.

(B) Bio-imaging of mice body at different time points (left) and fluorescence intensity ratio of thoracic cavity against abdomen (right, n = 3).

(C) Mice were sacrificed at 4 and 6 h post antibody administration and dissected organs were imaged (n = 3). Lu, lung; K, kidney; H, heart; S, spleen; Li, liver.

(D) Quantification of organ tissue fluorescence signal.