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. 2021 Dec 4;57(3):360–369. doi: 10.1038/s41409-021-01539-9

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© The Author(s) 2021, corrected publication 2025

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Fig. 7 — The fatigued and non-fatigued groups were compared to each other and to the HC using linear mixed models. The p values shown are derived from those models. The comparisons to HC were age-adjusted. Since the HC only completed 4 blocks of the Stroop task, the HC data was compared to the first 4 blocks during session 1. Refer to the materials and methods section for details. A The fatigued group had significantly lower NS EDR amplitudes compared to the non-fatigued group, both before and after methylphenidate administration, as well as lower amplitudes compared to HC before methylphenidate. B, C The task-related EDR amplitudes and task-related EDL increases were significantly lower in the fatigued group compared to HC, before methylphenidate. D There was a significant correlation between EDL increase and mean prefrontal cortex activation in the non-fatigued but not the fatigued group, before methylphenidate. HC Healthy controls, EDR Electrodermal Response, NS EDR Non-specific EDR, EDL Electrodermal Level.