Extended Data Fig. 6 |. Role of PV^GPe-SNr and PV^GPe-PF in reversal learning test for discriminated operant response in lever-pressing system.

a, A schematic diagram for behavioral task. After the rule switch, active lever becomes inactive, and vice versa. b-d, Traces of z-scored ΔF/F (averaged across 5 mice) from PV^GPe-PF axons during session start (b), from start to lever pressing (c) and during lever pressing (d) at the different behavioral stage. Note that the fiber photometry signals for interval between session start and lever pressing was interpolated because of the difference in interval. e-g, Traces of z-scored ΔF/F (averaged across 4 mice) from PV^GPe-SNr axons during session start (e), from start to lever pressing (f) and during lever pressing (g) at the different behavioral stage. Note that the fiber photometry signals for interval between session start and lever pressing was interpolated because of the difference in interval. h-k, Activation of PV^GPe-SNr and PV^GPe-PF axons did not affect association (h, j) and reversal (i, k) in operant discrimination tasks. l-o, Inhibition of PV^GPe-SNr and PV^GPe-PF axons did not affect association (l, n) and reversal (m, o) in operant discrimination tasks. Shaded areas accompanying the z-scored ΔF/F traces in b-g indicate SEM. All other data are presented as mean ± SEM.