TABLE 1.
Antigen and culture results from fungal burden experiment in animals remaining in a survival study that were sacrificed at day 29 following challenge with a 105 inoculum
| Regimena (no. of mice) | Median fungal burden (mean ± SD)
|
|||
|---|---|---|---|---|
| Antigen level (EU)
|
Quantitative culture (CFU/g of organ)
|
|||
| Lung | Spleen | Lung | Spleen | |
| Ampho 2.5 (n = 9) | 2.7 (2.9 ± 1.4) | 1.2 (1.5 ± 1.2) | 0 (1.07 × 101 ± 3.22 × 101) | 0 (3.39 × 101 ± 6.75 × 101) |
| Itra 75 (n = 9) | 1.0 (2.0 ± 1.6) | 5.8b (4.8 ± 2.2) | 1.34 × 104b (1.41 × 104 ± 4.72 × 103) | 3.99 × 104b (3.99 × 104 ± 1.09 × 104) |
| Itra 5.0 (n = 4) | 7.7b (7.9 ± 0.8) | 7.1b (7.3 ± 0.5) | 2.31 × 105b (1.38 × 105 ± 2.05 × 105) | 5.06 × 105 (2.86 × 105 ± 3.43 × 105) |
| SCH 56592 5.0 (n = 9) | 4.0 (3.7 ± 0.9) | 1.7 (1.7 ± 0.6) | 1.11 × 104 (8.33 × 103 ± 5.10 × 103) | 1.69 × 104 (1.51 × 104 ± 6.91 × 103) |
a
Abbreviations: Ampho 2.5, amphotericin B at 2.5 mg/kg qod; Itra 75 and 5.0, itraconazole at 75 and 5 mg/kg/day, respectively; SCH 56592 5.0, SCH 56592 at 5 mg/kg/day.
b
Statistically significantly different from (higher than) the value for the group of mice given amphotericin B at 2.5 mg/kg qod (P < 0.05).