TABLE 2.
Antigen and culture results in fungal burden experiment in animals sacrificed at day 14 following challenge with a 104 inoculum
| Regimena (no. of mice) | Median fungal burden (mean ± SD)
|
|||
|---|---|---|---|---|
| Antigen level (EU)
|
Quantitative culture (CFU/g of organ)
|
|||
| Lung | Spleen | Lung | Spleen | |
| Ampho 2.0 (n = 10) | 5.0b (6.4 ± 4.7) | 2.5b (4.0 ± 4.1) | 1.97 × 103b (2.68 × 105 ± 8.37 × 105) | 0b (4.51 × 102 ± 1.27 × 103) |
| Ampho 0.2 (n = 10) | 22.7 (22.2 ± 1.6) | 20.0 (19.7 ± 1.5) | 3.09 × 107 (3.15 × 107 ± 1.74 × 107) | >3.94 × 106c (3.68 × 106 ± 9.81 × 105) |
| Itra 75 (n = 9) | 5.5b (5.3 ± 2.1) | 1.5b (1.7 ± 0.6) | Not evaluable | 2.47 × 102b (3.99 × 102 ± 3.75 × 102) |
| Itra 10 (n = 9) | 24.8 (24.6 ± 2.3) | 19.8 (18.8 ± 3.3) | 2.25 × 107 (2.27 × 107 ± 1.08 × 107) | >2.13 × 106c (2.81 × 106 ± 1.99 × 106) |
| SCH 56592 1.0 (n = 9) | 5.6b (6.9 ± 3.1) | 1.5b (2.3 ± 1.2) | 3.15 × 103b (5.68 × 105 ± 1.69 × 106) | 7.41 × 102b (1.08 × 103 ± 1.51 × 103) |
| SCH 56592 0.1 (n = 7) | 21.2 (22.2 ± 1.9) | 20.0 (19.1 ± 2.5) | 3.31 × 107 (3.29 × 107 ± 2.41 × 107) | 7.70 × 105 (6.76 × 105 ± 3.93 × 105) |
| None (Untreated control) (n = 8) | 23.9 (23.8 ± 2.6) | 19.7 (19.7 ± 1.2) | 1.81 × 107 (2.79 × 107 ± 2.97 × 107) | 6.37 × 105 (1.14 × 106 ± 1.03 × 106) |
a
Abbreviations: Ampho 2.0 and 0.2, amphotericin B at 2.0 and 0.2 mg/kg qod, respectively; Itra 75 and 10, itraconazole at 75 and 10 mg/kg/day, respectively; SCH 56592 1.0 and 0.1, SCH 56592 at 1.0 and 0.1 mg/kg/day, respectively.
b
Statistically significantly different from (lower than) the value for the untreated controls (P < 0.0001).
c
Statistically significantly different from (greater than) the value for the untreated controls (P < 0.05).