TABLE 3.
Antigen and culture results in a second fungal burden experiment in animals sacrificed at day 14 following challenge with a 104 inoculum
| Regimena (no. of mice) | Median fungal burden (mean ± SD)
|
|||
|---|---|---|---|---|
| Antigen level (EU)
|
Quantitative culture (CFU/g of organ)
|
|||
| Lung | Spleen | Lung | Spleen | |
| Ampho 2.0 (n = 7) | 3.1b (3.6 ± 1.1) | 1.2b (1.4 ± 0.4) | 1.03 × 103 (2.66 × 103 ± 4.44 × 103) | 0b (3.17 × 102 ± 6.65 × 102) |
| Ampho 0.2 (n = 7) | 16.8 (16.2 ± 1.1) | 14.4 (14.4 ± 1.4) | 2.55 × 106 (2.60 × 106 ± 4.72 × 105) | 2.34 × 105 (3.19 × 105 ± 2.63 × 105) |
| Itra 10 (n = 6) | 16.3 (16.7 ± 0.8) | 16.0 (15.7 ± 0.8) | 2.80 × 106 (2.83 × 106 ± 1.47 × 105) | 3.20 × 105 (4.21 × 105 ± 3.11 × 105) |
| Itra 1.0 (n = 7) | 16.9 (17.0 ± 0.5) | 16.3 (16.5 ± 0.8) | 2.54 × 106 (2.53 × 106 ± 1.08 × 105) | 1.15 × 106 (9.75 × 105 ± 5.05 × 105) |
| SCH 56592 1.0 (n = 7) | 2.6b (2.6 ± 0.5) | 1.1b (1.1 ± 0.1) | 1.14 × 102b (1.15 × 102 ± 1.59 × 102) | 0b (3.7 × 101 ± 9.8 × 101) |
| SCH 56592 0.1 (n = 7) | 17.5 (16.2 ± 2.9) | 15.5 (13.9 ± 5.0) | 3.42 × 106 (3.16 × 106 ± 8.74 × 105) | 1.13 × 105b (1.38 × 105 ± 9.62 × 104) |
| SCH 56592 0.1 (n = 7) | 19.0 (18.7 ± 1.1) | 18.2 (18.4 ± 0.6) | 2.66 × 106 (2.65 × 106 ± 3.62 × 105) | 1.03 × 106 (1.43 × 106 ± 9.05 × 105) |
| None (untreated control) (n = 7) | 17.7 (18.0 ± 1.3) | 17.1 (17.1 ± 0.7) | 2.48 × 106 (2.35 × 106 ± 9.50 × 105) | 2.51 × 106 (2.62 × 106 ± 1.15 × 106) |
a
Abbreviations: Ampho 2.0 and 0.2, amphotericin B at 2.0 and 0.2 mg/kg qod, respectively; Itra 10 and 1.0, itraconazole at 10 and 1.0 mg/kg/day, respectively; SCH 56592 1.0 and 0.1, SCH 56592 at 1.0 and 0.1 mg/kg/day, respectively.
b
Statistically significantly different from (lower than) the value for the untreated controls (P < 0.0001).