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. 2022 Feb 24;10:728771. doi: 10.3389/fcell.2022.728771

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Copyright © 2022 Yan, Zhang, Ling, Zhu, Mei, Yang, Zhang, Huo and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CTLA-4 activates ATM by anchoring the ATM inhibitor PP2A in the cytoplasm following transient treatment with zeocin in T cells, exacerbating the DNA damage response and inducing apoptosis.