TABLE 2.
Comparative activities of quinolones against ofloxacin-susceptible and ofloxacin-resistant S. pneumoniae isolates
| Strain and quinolone | No. of strains for which MICs (μg/ml) were as follows:
|
% Resistancea | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||
| Ofloxacin-susceptible strains (n = 124) | ||||||||||
| Ofloxacin | 1 | 10 | 107 | 6 | 0 | |||||
| Levofloxacin | 12 | 107 | 5 | 0 | ||||||
| Sparfloxacin | 9 | 81 | 34 | 0 | ||||||
| Grepafloxacin | 44 | 69 | 11 | 0 | ||||||
| Trovafloxacin | 97 | 26 | 1 | 0 | ||||||
| Clinafloxacin | 123 | 1 | 0 | |||||||
| Ofloxacin-resistant strains (n = 36) | ||||||||||
| Ofloxacin | 5 | 13 | 19 | 100 | ||||||
| Levofloxacin | 5 | 13 | 18 | 86 | ||||||
| Sparfloxacin | 1 | 9 | 1 | 15 | 10 | 97 | ||||
| Grepafloxacin | 7 | 3 | 3 | 18 | 4 | 1 | 81 | |||
| Trovafloxacin | 7 | 4 | 6 | 8 | 10 | 1 | 53 | |||
| Clinafloxacin | 6 | 28 | 2 | |||||||
a
Based on approved NCCLS resistance breakpoints.