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. 2022 Mar 9;12:4150. doi: 10.1038/s41598-022-08104-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytokines and chemokines with higher expression levels in young and aged BALB/c mice compared to those in young C57BL/6 J mice from early to middle phase of SARS-CoV-2 infection. Left-lung homogenates in HBSS were used to measure multiplex cytokines and chemokines using the Bio-plex suspension array system. Of the 32 cytokines and chemokines measured, eight are shown in this figure. Data are presented as mean ± SD. (young group, n = 3–4 per time point; aged group, n = 2–5 per time point). P-values were calculated using one-way ANOVA followed by Tukey’s test. Asterisks indicate significant differences among young C57BL/6 J, young BALB/c, and aged BALB/c mice.