TABLE 2.
PAEs of fluoroquinolones (1× MIC) alone and in combination with NorA inhibitors
| Regimena | Mean PAE (h) ± SD on:
|
||
|---|---|---|---|
| SA 1199 | SA 1199B | SA 1199-3 | |
| Norfloxacin | 0.9 ± 0.1 | 0.6 ± 0.0 | 0.2 ± 0.4 |
| Norfloxacin + reserpine | 4.5 ± 0.9 | 1.1 ± 0.1 | 0.4 ± 0.5 |
| Norfloxacin + omeprazole | 2.5 ± 0.6 | 1.3 ± 0.1 | 1.1 ± 0.1 |
| Ciprofloxacin | 1.4 ± 0.2 | 0.5 ± 0.1 | 1.6 ± 0.2 |
| Ciprofloxacin + reserpine | 2.8 ± 0.1 | 3.2 ± 0.0 | 3.5 ± 2.2 |
| Ciprofloxacin + omeprazole | 3.8 ± 0.1 | 2.4 ± 0.2 | 3.6 ± 1.1 |
| Levofloxacin | 1.4 ± 0 | 1.6 ± 0.1 | 1.3 ± 0.2 |
| Levofloxacin + reserpine | 1.7 ± 0.2 | 5.0 ± 0.1 | 1.0 ± 0.2 |
| Levofloxacin + omeprazole | 1.5 ± 0 | 3.1 ± 0.1 | 1.0 ± 0.1 |
a
Reserpine and omeprazole concentrations were 20 and 100 μg/ml, respectively.