Fig. 4. 89Zr-VRC01 uptake is preferentially increased in iliac and femoral bone marrow in participants with HIV compared with uninfected volunteers 3 days following injection.
a Representative axial PET-MR images showing tracer uptake in axial marrow in representative viremic, ART suppressed and uninfected participants. rSUVmax and rSUV mean values for b iliac and c femoral shaft bone marrow 89Zr-VRC01 uptake from 3-dimensional gating at imaging day 0, day 1, and day 3. Minimal uptake was observed in osseus (femoral shaft) bone at any time point in all cohorts (d). SUV standardized uptake value; rSUV blood pool-adjusted 89Zr-VRC01 standardized uptake value (tissue to blood pool SUV ratio); P values <0.05 and <0.01 represented by * and **, respectively from two-sided non-parametric analyses (Mann–Whitney tests for analyses involving two groups and Kruskal–Wallis tests for analyses involving three groups). Mean and standard error bars are shown. Control N = 4 on day 0 and day 1, viremic case N = 4 and 3 on day 0 and day 1, respectively (‡statistical analyses not performed on day 1 as one viremic participant missed this visit). Control and viremic and ART case N = 5 on day 3. Source data are provided as a Source Data file.