Table 2.
The longitudinal neutralizing antibody responses to four serotype dengue viruses with different dose schedules in a phase 2 trial (NCT02302066).
| Dose schedules | Two-dose primary | One primary | One primary dose plus 1-year boost | placebo | |||||
|---|---|---|---|---|---|---|---|---|---|
| Outcomes | Geometric mean titers (95% CI) | Seroconversion rates (%, 95%CI) | Geometric mean titers (95% CI) | Seroconversion rates (%, 95%CI) | Geometric mean titers (95% CI) | Seroconversion rates (%, 95%CI) | Geometric mean titers (95% CI) | Seroconversion rates (%, 95%CI) | |
| 6-month | DENV1 GMT | 449 (293 to 688) | 100.0 (95.7 to 100.0) | 464 (330 to 653) | 97.1 (93.3 to 99.0) | 539 (391 to 742) | 99.4 (96.8 to 100.0) | 56 (29 to 106) | 49.4 (38.1 to 60.7) |
| DENV2 GMT | 1462(1072 to 1993) | 98.8 (93.5 to 100.0) | 1683 (1334 to 2124) | 99.4 (96.8 to 100.0) | 1335 (1067 to 1670) | 99.4 (96.8 to 100.0) | 77 (40 to 150) | 49.4 (38.1 to 60.7) | |
| DENV3 GMT | 150 (97 to 233) | 98.8 (93.5 to 100.0) | 166 (118 to 235) | 92.9 (88.0 to 96.3) | 174 (126 to 241) | 93.1 (88.3 to 96.4) | 37 (22 to 65) | 48.1 (36.9 to 59.5) | |
| DENV4 GMT | 109 (73 to 163) | 92.8 (84.9 to 97.3) | 110 (81 to 149) | 90.6 (85.2 to 94.5) | 92 (69 to 124) | 85.1 (78.9 to 90.0) | 22 (14 to 35) | 44.4 (33.4 to 55.9) | |
| 18-month | DENV1 GMT | 476 (286 to 791) | 95.1 (87.8 to 98.6) | 461 (329 to 647) | 97.0 (93.2 to 99.0) | 1056 (804 to 1388) | 98.8 (95.9 to 99.9) | 92 (49 to 173) | 62.5 (51.0 to 73.1) |
| DENV2 GMT | 1212 (842 to 1744) | 98.8 (93.3 to 100.0) | 1242 (947 to 1628) | 97.6 (94.0 to 99.3) | 1457 (1182 to 1796) | 100.0 (97.9 to 100.0) | 177 (93 to 337) | 68.8 (57.4 to 78.7) | |
| DENV3 GMT | 286 (171 to 478) | 95.1 (87.8 to 98.6) | 298 (205 to 433) | 92.3 (87.1 to 95.8) | 548 (411 to 730) | 98.3 (95.0 to 99.6) | 78 (44 to 137) | 63.8 (52.2 to 74.2) | |
| DENV4 GMT | 98 (65 to 150) | 87.7 (78.5 to 93.9) | 102 (75 to 139) | 86.9 (80.8 to 91.6) | 172 (133 to 222) | 97.1 (93.3 to 99.0) | 33 (21 to 52) | 57.5 (45.9 to 68.5) | |
| 48-month | DENV1 GMT | 378 (226 to 632) | 96.9 (89.3 to 99.6) | 421 (285 to 622) | 94.7 (89.5 to 97.9) | 719 (538 to 960) | 100.0 (97.3 to 100.0) | 100 (50 to 201) | 68.3 (55.3 to 79.4) |
| DENV2 GMT | 1052 (732 to 1511) | 100.0 (94.5 to 100.0) | 1319 (970 to 1794) | 98.5 (94.7 to 99.8) | 1200 (927 to 1553) | 100.0 (97.3 to 100.0) | 208 (99 to 437) | 68.3 (55.3 to 79.4) | |
| DENV3 GMT | 183 (113 to 298) | 95.4 (87.1 to 99.0) | 201 (135 to 298) | 90.2 (83.9 to 94.7) | 288 (211 to 392) | 97.8 (93.7 to 99.5) | 71 (37 to 139) | 63.5 (50.4 to 75.3) | |
| DENV4 GMT | 152 (97 to 239) | 90.8 (81.0 to 96.5) | 164 (114 to 236) | 91.0 (84.8 to 95.3) | 219 (165 to 290) | 99.3 (96.0 to 100.0) | 46 (26 to 82) | 60.3 (47.2 to 72.4) | |