TABLE 2.
Mefloquine pharmacokinetics in the presence of artesunatea
| Parameter | Group
|
|||
|---|---|---|---|---|
| A | B | C | D | |
| Cmax (ng/ml) | 1,614 (710–2,881) (n = 27) | 1,377 (838–3,106) (n = 29) | 1,757 (422–3,051) (n = 27) | 1,962 (809–4,137) (n = 27) |
| AUC (ng/ml · day) | 25,322 (7,936–49,354) (n = 26) | 28,654 (17,827–53,788) (n = 25) | 21,750 (6,441–52,491) (n = 24) | 28,196 (19,133–73,716) (n = 22) |
| CI/f (liters/kg/day) | 0.98 (0.51–3.15) (n = 26) | 0.87 (0.46–1.40) (n = 25) | 1.15 (0.48–3.88) (n = 24) | 0.89 (0.34–1.31) (n = 22) |
| V/f (liters/kg) | 18.5 (8.2–41.6) (n = 26) | 18.1 (6.2–30.5) (n = 25) | 18.8 (11.3–60.7) (n = 24) | 17.5 (5.5–28.1) (n = 22) |
| t1/2 (days) | 13.6 (8.2–31.3) (n = 26) | 12.9 (7.9–30.7) (n = 25) | 11.6 (6.9–16.6) (n = 24) | 12.1 (6.5–33.2) (n = 22) |
| AUC above 500 ng/ml (ng/ml · day) | 6,037 (315–22,106) (n = 26) | 8,432 (2,379–33,738) (n = 25) | 5,303 (0–23,742) (n = 27) | 7,759 (4,540–39,693) (n = 22) |
| Time above 500 ng/ml (days) | 19 (3–26) (n = 27) | 23 (11–26) (n = 25) | 14 (0–26) (n = 27) | 22 (11–26) (n = 23) |
a
Median (range) and number of patients with available data.