Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 24;13:822604. doi: 10.3389/fimmu.2022.822604

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Ren, Li, Di, Xiong, Zhang, Ma, Bian, Lang, Ye and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Diagram showing the mechanism by which E₂ negatively regulates TGF-βRI gene transcription. Under the condition of IRI, a decrease in the E₂ level by OVX reduces the transcriptional inhibition of TGF-βRI, and activating TGF-βRI activates pSMAD2/3, thus promoting the release of proinflammatory factors. After supplementation, E₂ enters the nucleus, binds to ERα, binds to the ERE of the TGF-βRI promoter, and represses its transcription.