Table 3.
Univariate and multivariate Cox regression analyses of mortality affected by admission 25(OH)D deficiency in patients with COVID-19a
| Variable | Dead | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Age (yr) | 67 (45–75) | 1.02 (1.01–1.04) | 0.031 | 1.01 (0.99–1.03) | 0.355 |
| Male | 21 (48.8) | 1.23 (0.68–2.25) | 0.491 | 1.12 (0.59–2.14) | 0.721 |
| BMI (kg/m2) | 26.1 (25.1–34.7) | 1.03 (0.99–1.08) | 0.156 | 1.03 (0.98–1.08) | 0.197 |
| CRP (mg/dl) | 4.3 (3.3–5.6) | 0.88 (0.74–1.03) | 0.117 | 0.80 (0.66–0.97) | 0.021 |
| Severe COVID-19 | 25 (58.1) | 3.45 (1.79–6.65) | <0.001 | 2.90 (1.46–5.77) | 0.002 |
| Number of comorbidities | 1 (1–3) | 0.94 (0.74–1.18) | 0.574 | 1.03 (0.81–1.31) | 0.802 |
| 25(OH)D at admission deficiency | 30.0 (69.8) | 2.18 (1.12–4.26) | 0.023 | 2.35 (1.15–4.78) | 0.019 |
Values are presented as median (interquartile range) or number (%) unless otherwise indicated.
25(OH)D: 25-hydroxyvitamin D; COVID-19: coronavirus disease 2019; HR: hazard ratio; CI: confidence interval; BMI: body mass index; CRP: C-reactive protein.
a
Multivariable analyses were conducted using Cox regression models utilizing the simultaneous method.