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. 2022 Feb 24;9:771679. doi: 10.3389/fcvm.2022.771679

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Copyright © 2022 Shaker, Abrams, Oppenheimer, Singer, Shaker, Fleck, Greenhawt and Grove.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Probabilistic sensitivity analysis. Probabilistic sensitivity analysis using triangular distributions (n = 10,000 simulations, assuming an average 1.5% annual SCA risk with upper and lower limits of 0.1%–6.0%) demonstrated SMART to be the most cost-effective strategy in 54.64% of simulations (WTP, $100,000 per QALY). (A) Cost-effectiveness acceptability curve. (B) Cost-effectiveness of 10,000 simulations shown with 95% confidence ellipse.