FIG. 8.

Comparison of inhibitory activities of ISIS 6547 (▨) and the 5′-methylcytidine-modified HCV antisense oligonucleotide ISIS 14803 ( ). Members of a group of eight female BALB/c mice were treated subcutaneously with oligonucleotide at 24 h and 2 h prior to infection and at 4 h after infection. Mice were infected by intraperitoneal injection of 10⁸ PFU of VHCV-IRES. At 24 h following infection, the luciferase activity in the livers was determined. A control group of infected mice treated with saline instead of oligonucleotide was used to determine 100% control luciferase activity. Data are represented as means ± standard errors of the means.