Table 2.

Univariate and multivariate Cox proportional hazards regression analyses of NT-proBNP for predicting cardiovascular events.

	Univariate analysis		Age- and sex-adjusted		Multivariate analysis
	HR (95%CI)	p-value	HR (95%CI)	p-value	HR (95%CI)	p-value
MACE
Log (NT-proBNP)	1.70 (1.53–1.89)	<0.001	1.46 (1.31–1.64)	<0.001	1.47 (1.31–1.66)	<0.001
Low	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
Median	2.11 (1.45–3.05)	0.001	1.94 (1.34–2.81)	0.001	1.88 (1.29–2.73)	0.001
High	4.29 (3.03–6.06)	<0.001	3.01 (2.09–4.34)	<0.001	2.99 (2.06–4.36)	<0.001
Hard endpoint
Log (NT-proBNP)	2.35 (2.06–2.69)	<0.001	1.67 (1.45–1.94)	<0.001	1.70 (1.45–1.99)	<0.001
Low	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
Median	3.07 (1.67–5.66)	0.001	2.61 (1.42–4.81)	0.001	2.52 (1.36–4.65)	0.003
High	10.29 (6.41–16.87)	<0.001	5.55 (3.08–9.98)	<0.001	5.44 (2.99–9.90)	<0.001
Cardiac mortality
Log (NT-proBNP)	3.07 (2.59–3.64)	<0.001	1.87 (1.55–2.26)	<0.001	1.84 (1.51–2.25)	<0.001
Low	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
Median	3.91 (1.50–9.21)	0.001	3.08 (1.18–8.05)	0.021	2.80 (1.07–7.33)	0.036
High	12.08 (5.61–19.63)	<0.001	6.99 (2.80–17.45)	<0.001	5.92 (2.34–14.96)	<0.001
All-cause mortality
Log (NT-proBNP)	2.98 (2.57–3.44)	<0.001	1.80 (1.53–2.11)	<0.001	1.74 (1.47–2.06)	<0.001
Low	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
Median	2.94 (1.41–6.12)	0.004	2.31 (1.11–4.82)	0.025	2.24 (1.07–4.67)	0.032
High	14.91 (7.88–21.18)	<0.001	5.36 (2.69–10.70)	<0.001	5.03 (2.51–10.09)	<0.001

MACE, major adverse cardiovascular events; NT-proBNP, N-terminal pro-brain natriuretic peptide; HR, hazard ratio; CI, confidence interval. Multivariate model is adjusted for age, sex, body mass index, family history of coronary artery disease, hypertension, smoking, diabetes, pre-revascularization, gensini score, left ventricular ejection fraction, low-density lipoprotein cholesterol, triglycerides, fasting plasma glucose, hypersensitive C-reactive protein and baseline statin use.