Table 3.
Univariate and multivariate Cox proportional hazards regression analyses of the combinations of NT-proBNP and hs-CRP for predicting cardiovascular events.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95%CI) | p | HR (95%CI) | p | |
| MACE | ||||
| NT-proBNP Low + Hs-CRP Low | 1.00 (Reference) | 1.00 (Reference) | ||
| NT-proBNP Median + Hs-CRP Low | 2.10 (1.27–3.46) | 0.004 | 1.89 (1.14–3.13) | 0.013 |
| NT-proBNP High + Hs-CRP Low | 4.28 (2.61–7.03) | <0.001 | 3.27 (2.02–5.29) | <0.001 |
| NT-proBNP Low + Hs-CRP High | 1.59 (0.86–2.93) | 0.14 | 1.43 (0.77–2.65) | 0.254 |
| NT-proBNP Median + Hs-CRP High | 2.81 (1.71–4.61) | <0.001 | 2.28 (1.38–3.77) | 0.001 |
| NT-proBNP High + Hs-CRP High | 5.15 (3.28–8.09) | <0.001 | 3.32 (1.99–5.53) | <0.001 |
| Hard endpoint | ||||
| NT-proBNP Low + Hs-CRP Low | 1.00 (Reference) | 1.00 (Reference) | ||
| NT-proBNP Median + Hs-CRP Low | 4.16 (1.58–10.92) | 0.004 | 3.44 (1.31–8.26) | 0.012 |
| NT-proBNP High + Hs-CRP Low | 10.69 (4.23–19.54) | <0.001 | 8.14 (3.23–17.51) | <0.001 |
| NT-proBNP Low + Hs-CRP High | 3.67 (1.25–10.73) | 0.018 | 2.94 (1.00–8.63) | 0.050 |
| NT-proBNP Median + Hs-CRP High | 6.42 (2.48–16.60) | <0.001 | 4.36 (1.68–11.35) | 0.003 |
| NT-proBNP High + Hs-CRP High | 15.21 (8.25–24.48) | <0.001 | 8.83 (3.45–18.62) | <0.001 |
| Cardiac mortality | ||||
| NT-proBNP Low + Hs-CRP Low | 1.00 (Reference) | 1.00 (Reference) | ||
| NT-proBNP Median + Hs-CRP Low | 6.02 (0.74–49.00) | 0.093 | 4.24 (0.52–34.58) | 0.178 |
| NT-proBNP High + Hs-CRP Low | 20.21 (6.84–38.50) | <0.001 | 15.38 (2.33–26.58) | 0.005 |
| NT-proBNP Low + Hs-CRP High | 9.13 (1.07–78.13) | 0.044 | 5.85 (0.68–50.45) | 0.108 |
| NT-proBNP Median + Hs-CRP High | 20.91 (2.80–36.39) | 0.003 | 10.79 (1.43–21.22) | 0.021 |
| NT-proBNP High + Hs-CRP High | 28.89 (10.57–44.88) | <0.001 | 16.30 (2.22–27.49) | 0.006 |
| All-cause mortality | ||||
| NT-proBNP Low + Hs-CRP Low | 1.00 (Reference) | 1.00 (Reference) | ||
| NT-proBNP Median + Hs-CRP Low | 5.46 (1.23–24.25) | 0.026 | 3.80 (0.85–16.90) | 0.080 |
| NT-proBNP High + Hs-CRP Low | 22.21 (7.77–36.54) | <0.001 | 10.25 (2.67–24.40) | 0.001 |
| NT-proBNP Low + Hs-CRP High | 7.32 (1.55–34.46) | 0.012 | 4.89 (1.03–23.15) | 0.046 |
| NT-proBNP Median + Hs-CRP High | 12.38 (2.91–52.57) | 0.001 | 6.31 (1.48–27.00) | 0.013 |
| NT-proBNP High + Hs-CRP High | 29.86 (13.07–43.82) | <0.001 | 11.76 (2.84–28.73) | 0.001 |
MACE, major adverse cardiovascular events; NT-proBNP, N-terminal pro-brain natriuretic peptide; hs-CRP, high sensitivity C-reactive protein; HR, hazard ratio; CI, confidence interval. Multivariate model is adjusted for age, sex, body mass index, family history of coronary artery disease, hypertension, smoking, diabetes, pre-revascularization, gensini score, left ventricular ejection fraction, low-density lipoprotein cholesterol, triglycerides, fasting plasma glucose and baseline statin use.