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. 2022 Feb 24;13:845684. doi: 10.3389/fimmu.2022.845684

Figure 2.

Figure 2

Urate transporters in the kidneys and intestine in humans. GLUT9 and URAT1 on the proximal tubule cells mediate renal urate reabsorption, while GLUT9 on the enterocytes mediate urate excretion in the intestine. ABCG2 is involved in urate export in both the intestine and the kidney. OAT1, OAT2 and OAT3 are present on the basolateral membrane of renal proximal tubule cells and mediates urate secretion.