Table 5.
The top 20 most frequent keywords, keywords extracted from titles and abstracts.
| Modified keywords | Frequency | Title | Frequency | Abstract | Frequency | Original keywords | Frequency |
|---|---|---|---|---|---|---|---|
| Multiple sclerosis | 25,191 | Multiple sclerosis patients | 2,253 | Multiple sclerosis MS | 23,513 | Multiple sclerosis | 21,194 |
| EAE | 3,374 | Experimental autoimmune encephalomyelitis | 2,158 | Central nervous system | 6,846 | Sclerosis | 1,595 |
| MRI | 3,292 | Relapsing_remitting multiple sclerosis | 1,178 | Experimental autoimmune encephalomyelitis | 4,825 | Multiple | 1,517 |
| Inflammatory | 1,577 | Central nervous system | 784 | Magnetic resonance imaging | 3,956 | MRI | 1,242 |
| Demyelinating disease | 1,507 | Progressive multiple sclerosis | 701 | Disability status scale | 3,765 | Demyelination | 1,129 |
| Autoimmune disease | 1,465 | Magnetic resonance imaging | 505 | Expanded disability status | 3,751 | Experimental autoimmune encephalomyelitis | 1,018 |
| Interferon | 1,358 | Experimental allergic encephalomyelitis | 380 | Autoimmune encephalomyelitis EAE | 3,524 | Magnetic resonance imaging | 997 |
| T-cells | 1,349 | Multiple sclerosis lesions | 342 | Nervous system CNS | 2,690 | Inflammation | 925 |
| Cognition | 989 | Myelin basic protein | 274 | Relapsing_remitting multiple sclerosis | 2,278 | Autoimmunity | 875 |
| CSF | 933 | Clinically isolated syndrome | 261 | Status scale EDSS | 2,142 | EAE | 857 |
| Cytokines | 834 | Secondary progressive multiple | 226 | Sclerosis MS patients | 2,100 | FATIGUE | 815 |
| Oligodendrocyte | 832 | Relapsing multiple sclerosis | 206 | Multiple sclerosis patients | 2,010 | Cerebrospinal fluid | 750 |
| Disability | 825 | Primary progressive multiple | 205 | Resonance imaging MRI | 1,985 | Disability | 694 |
| Fatigue | 815 | Remitting multiple sclerosis | 197 | Myelin basic protein | 1,543 | Depression | 645 |
| Interleukins | 737 | Randomized controlled trial | 190 | Cerebrospinal fluid CSF | 1,540 | Quality of life | 613 |
| NMOSD | 715 | Relapsing remitting multiple | 186 | Clinically isolated syndrome | 1,158 | Microglia | 610 |
| Depression | 669 | Neuromyelitis optica spectrum | 178 | Progressive multiple sclerosis | 1,153 | Cytokines | 607 |
| Optic nerve | 645 | Myelin oligodendrocyte glycoprotein | 175 | Multiple sclerosis RRMS | 1,127 | Cognition | 605 |
| Epidemiology | 634 | Pediatric multiple sclerosis | 157 | Myelin oligodendrocyte glycoprotein | 1,085 | Rehabilitation | 604 |
| Rehabilitation | 629 | Stem cell transplantation | 147 | Peripheral blood mononuclear | 807 | Epidemiology | 594 |