Table 3.
Data analysis using the crude and multiple Cox regression models for the composite outcome comprising mortality, ICU admission and intubation.
| Variable | Level | Total (n = 583) | Event (n = 95, 16.3%) | Crude model | Multiple model | ||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||||
| Age (mean ± S.D) | 61.4 ± 20.4 | 73.6 ± 15.5 | 1.03 (1.02, 1.04) | 0.001 | 1.02 (1.01, 1.03) | 0.016 | |
| Sex | Female (n,%) | 278 (47.7) | 35 (12.6) | 1 (Baseline) | 0.015 | 1 (Baseline) | 0.007 |
| Male (n, %) | 305 (52.3) | 60 (19.7) | 1.68 (1.11, 2.55) | 1.82 (1.18, 2.83) | |||
| Statin | Yes (n, %) | 162 (27.8) | 8 (11.1) | 1 (Baseline) | 0.002 | 1 (Baseline) | 0.048 |
| 0.43 (0.26, 0.73) | 0.57 (0.33, 0.99) | ||||||
| Sign and symptoms | |||||||
| Fever | Yes (n, %) | 342 (58.7) | 62 (18.1) | 1 (Baseline) | 0.001 | 1 (Baseline) | 0.052 |
| 0.49 (0.32, 0.75) | 0.62(0.38, 1.01) | ||||||
| Cough | Yes (n, %) | 417 (71.5) | 74 (17.7) | 1 (Baseline) | 0.012 | 1 (Baseline) | 0.905 |
| 0.53 (0.33, 0.87) | 0.91(0.51, 1.59) | ||||||
| Muscular pain | Yes (n, %) | 134 (23.0) | 24 (17.9) | 1 (Baseline) | 0.354 | – | – |
| 1.25 (0.78, 1.98) | – | – | |||||
| ARDS | Yes (n, %) | 139 (23.8) | 34 (24.5) | 1 (Baseline) | – | – | |
| 1.03 (0.99, 4.28) | 0.882 | – | – | ||||
| consciousness | Yes (n, %) | 15 (2.6) | 8 (53.3) | 1 (Baseline) | 0.052 | – | – |
| 2.06 (0.99, 4.8) | – | – | |||||
| Nausea | Yes (n, %) | 69 (11.8) | 10 (14.5) | 1 (Baseline) | 0.447 | – | – |
| 1.29 (0.67, 2.50) | – | – | |||||
| Anorexia | Yes (n, %) | 45 (7.7) | 5 (11.1) | 1 (Baseline) | 0.423 | – | – |
| 0.69 (0.28, 1.71) | – | – | |||||
| Comorbidities | |||||||
| Diabetes | Yes (n, %) | 81 (13.9) | 15 (18.5) | 1 (Baseline) | 0.702 | – | – |
| 1.11 (0.64, 1.94) | – | – | |||||
| Cardiovascular disease | Yes (n, %) | 146 (25.0) | 32 (21.9) | 1 (Baseline) | 0.015 | 1 (Baseline) | 0.972 |
| 1.70 (1.11, 2.60) | 1.01 (0.62, 1.64) | ||||||
| Asthma | Yes (n, %) | 16 (2.7) | 4 (25.0) | 1 (Baseline) | 0.093 | – | – |
| 2.37 (0.87, 6.50) | – | – | |||||
| Norologic | Yes (n, %) | 9 (1.5) | 3 (33.3) | 1 (Baseline) | 0.960 | – | – |
| 1.03 (0.32, 3.29) | – | – | |||||
| Hypertention | Yes (n, %) | 27 (17.4) | 155 (26.6) | 1 (Baseline) | 0.964 | – | – |
| 0.99 (0.63, 1.55) | – | – | |||||
| Other | |||||||
| pO2 | < =90% | 394 (67.8) | 83 (21.1) | 1 (Baseline) | 0.002 | 1 (Baseline) | 0.084 |
| >90% | 187 (32.2) | 12 (6.4) | 0.30 (0.17, 0.56) | 0.56 (0.29, 1.08) | |||
| CT scan | Yes (n, %) | 165 (28.3) | 25 (15.2) | 1 (Baseline) | 0.298 | – | – |
| 0.78 (0.49, 1.24) | – | – | |||||
| smoke | Yes (n, %) | 33 (5.7) | 8 (24.2) | 1 (Baseline) | 0.030 | 1 (Baseline) | 0.312 |
| 2.24 (1.08, 4.66) | 1.49 (0.69, 3.21) | ||||||
| Opium | Yes (n, %) | 14 (2.4) | 7 (50.0) | 1 (Baseline) | 0.223 | – | – |
| 1.63 (0.74, 3.54) | – | – | |||||
| temperature | mean ± S.D | 37.1 ± 0.7 | 37.2 ± 0.6 | 0.98 (0.58, 1.66) | 0.951 | – | – |
| Laboratory measures | |||||||
| WBC | mean ± S.D | 8.5 ± 6.5 | 10.1 ± 4.6 | 1.03 (1.01, 1.04) | 0.001 | 1.02 (0.99, 1.05) | 0.271 |
| HB | mean ± S.D | 12.5 ± 1.8 | 12.3 ± 1.9 | 0.92 (0.81, 1.03) | 0.915 | – | – |
| PLT | mean ± S.D | 199.4 ± 93.5 | 199.6 ± 88.7 | 1.00 (0.99, 1.01) | 0.712 | – | – |
| Neut | mean ± S.D | 74.2 ± 13.8 | 79.1 ± 14.4 | 1.02 (1.01, 1.04) | 0.020 | 1.02 (0.98, 1.06) | 0.327 |
| Lymph | mean ± S.D | 18.8 ± 11.5 | 14.7 ± 11.3 | 0.97 (0.95, 0.99) | 0.005 | 1.02 (0.97, 1.06) | 0.491 |
| BUN | mean ± S.D | 17.4 ± 12.3 | 22.9 ± 17.9 | 1.03 (1.02, 1.04) | 0.001 | 1.04 (1.02, 1.06) | 0.012 |
| MPV | mean ± S.D | 9.9 ± 1.03 | 10.0 ± 1.1 | 0.99 (0.81, 1.20) | 0.913 | – | – |
| Cr | mean ± S.D | 1.2 ± 0.9 | 1.5 ± 1.7 | 1.13 (1.02, 1.25) | 0.016 | 1.18 (0.98, 1.42) | 0.079 |
| CRP | mean ± S.D | 1.1 ± 0.7 | 1.2 ± 0.7 | 1.18 (0.89, 1.54) | 0.243 | – | – |
| RDW | mean ± S.D | 14.1 ± 1.8 | 14.9 ± 2.1 | 1.14 (1.05, 1.25) | 0.003 | 1.06 (0.96, 1.18) | 0.235 |
Extended Cox Model; P < 0.05 was considered significant.