Table 3.
Previously reported significant AAM-related genes.
| Authors | SNP | Gene | Pa | PTWASb |
|---|---|---|---|---|
| John RB Perry, et al. (32) | rs10148448 | MEG3 | 2.10E-04 | 2.52E-07 |
| Diana L. Cousminer, et al. (33) | rs12917823 | MAPK3 | P < 5.00E-02 | 1.22E-03 |
| rs17046434 | ADCY3 | P < 5.00E-02 | 2.42E-02 | |
| rs7759938 | LIN28B | P < 5.00E-02 | 6.37E-49 | |
| Cathy E. Elks, et al. (34). | rs7759938 | LIN28B | 1.60E-58 | 6.37E-49 |
| rs10148448 | BEGAIN | 1.70E-10 | 2.55E-06 | |
| rs4929923 | TRIM66 | 2.40E-08 | 1.38E-09 | |
| rs3905330 | RBM6 | 1.40E-09 | 8.60E-05 | |
| rs633715 | SEC16B | 1.50E-09 | 4.07E-03 | |
| rs4955420 | KLHDC8B | 1.80E-09 | 6.13E-06 | |
| rs16938437 | PHF21A | 1.40E-09 | 9.98E-09 | |
| rs2687729 | EEFSEC | 1.00E-08 | 2.51E-11 | |
| rs8104651 | OLFM2 | 4.60E-10 | 1.10E-07 | |
| rs939317 | ECE2 | 2.30E-09 | 4.89E-03 | |
| rs12641981 | GNPDA2 | 8.70E-08 | 3.85E-02 | |
| rs12056794 | MSRA | 2.40E-02 | 1.00E-02 | |
| Nicholas Mancuso, et al. (35). | rs6580698 | CCDC65 | P < 5.00E-08 | 7.30E-05 |
| rs7330016 | COG6 | P < 5.00E-08 | 4.40E-02 | |
| rs12917823 | INO80E | P < 5.00E-08 | 2.47E-05 | |
| rs3761919 | NUCKS1 | P < 5.00E-08 | 4.86E-08 | |
| rs4717903 | PMS2P5 | P < 5.00E-08 | 6.58E-04 | |
| rs3761919 | RAB7L1 | P < 5.00E-08 | 9.47E-07 | |
| rs4717903 | STAG3L2 | P < 5.00E-08 | 4.37E-08 | |
| rs2274351 | TMEM180 | P < 5.00E-08 | 2.24E-04 |
a
P values of previously reported AAM-related genes.
b
Significant TWAS-identified genes associated with AAM in present research.