Table 1.
Dissociation constant and thermodynamic data for the target Hsp90N binding with its ligand NVP-AUY922 at 25°C.
| Items | Thermodynamic data (Mean ± SD, n = 4) |
|---|---|
| N | 0.78 ± 0.04 |
| K d (nM) | 5.10 ± 2.10 |
| ΔG a (kcal/mol) | −11.50 |
| ΔH a (kcal/mol) | −11.40 ± 0.30 |
| TΔS a (kcal/mol) | 0.10 |