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. 2022 Feb 24;13:783016. doi: 10.3389/fgene.2022.783016

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Copyright © 2022 Yang, Zhang, Li, Dam, Huang, Wang, Qiu, Sun, Chen, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A docking analysis of CLDN4 and TGFβ1. (B) (C) The protein of CLDN4 levels was increased in human CRC tissues (n = 5, *p < 0.05; **p < 0.01). (D) CLDN4 and CLDN11 mRNA levels were respectively increased and decreased in human CRC tissues (n = 10, *p < 0.05; **p < 0.01). (E) (F) (G) Western blot and qRT-PCR showed TGFβ1 and CLDN4 were remarkably downregulated at both protein and mRNA levels after treatment with LY364947 at 5.0 and 10.0 uM/ml, respectively, on HT29 cells. (H) (I) (J) Western blot and qRT-PCR showed TGFβ1 and CLDN4 were remarkably downregulated at both protein and mRNA levels after treatment with LY364947 at 5.0 and 10.0 uM/ml, respectively, on HCT116 cells. TGFβ1 reduced CLDN4 expression in colorectal cancer cell lines.