Table 1.

Three-fold cross-validation performance of unimodal prediction models using radiomics and our proposed MMIDFNet.

Methods	Modality	Fold	ACC	AUC	SEN	SPE	PPV	NPV
Radiomics	T1	1	0.730	0.734	0.546	0.792	0.807	0.865
		2	0.689	0.755	0.522	0.765	0.748	0.844
		3	0.699	0.737	0.610	0.792	0.682	0.812
		Average	0.706	0.742	0.559	0.783	0.746	0.840
		95% CI	[0.672, 0.740]	[0.724, 0.760]	[0.487, 0.632]	[0.758, 0.808]	[0.646, 0.846]	[0.798, 0.883]
	T2	1	0.703	0.775	0.554	0.787	0.657	0.824
		2	0.743	0.827	0.596	0.816	0.722	0.875
		3	0.712	0.712	0.560	0.820	0.615	0.843
		Average	0.719	0.771	0.570	0.808	0.665	0.847
		95% CI	[0.686, 0.753]	[0.679, 0.863]	[0.534, 0.606]	[0.779, 0.836]	[0.578, 0.751]	[0.806, 0.889]
	T1ce	1	0.838	0.908	0.706	0.890	0.867	0.928
		2	0.784	0.841	0.650	0.854	0.770	0.905
		3	0.822	0.856	0.756	0.903	0.752	0.902
		Average	0.815	0.868	0.704	0.882	0.796	0.912
		95% CI	[0.770, 0.859]	[0.812, 0.925]	[0.619, 0.789]	[0.842, 0.923]	[0.697, 0.895]	[0.889, 0.934]
	Flair	1	0.730	0.788	0.570	0.792	0.763	0.881
		2	0.685	0.718	0.557	0.787	0.625	0.813
		3	0.743	0.740	0.585	0.810	0.756	0.888
		Average	0.719	0.749	0.571	0.796	0.715	0.861
		95% CI	[0.671, 0.768]	[0.691, 0.806]	[0.548, 0.593]	[0.777, 0.816]	[0.590, 0.839]	[0.794, 0.927]
MMIDFNet	T1	1	0.757	0.724	0.572	0.821	0.813	0.894
		2	0.689	0.696	0.509	0.767	0.663	0.890
		3	0.712	0.780	0.516	0.777	0.701	0.873
		Average	0.719	0.733	0.532	0.788	0.726	0.886
		95% CI	[0.664, 0.775]	[0.665, 0.802]	[0.477, 0.588]	[0.742, 0.834]	[0.601, 0.850]	[0.868, 0.904]
	T2	1	0.743	0.835	0.542	0.794	0.742	0.907
		2	0.730	0.749	0.560	0.820	0.687	0.854
		3	0.726	0.788	0.591	0.822	0.642	0.853
		Average	0.733	0.791	0.564	0.812	0.690	0.871
		95% CI	[0.719, 0.747]	[0.722, 0.860]	[0.525, 0.604]	[0.787, 0.837]	[0.610, 0.770]	[0.822, 0.921]
	T1ce	1	0.838	0.907	0.764	0.885	0.842	0.909
		2	0.824	0.885	0.667	0.897	0.749	0.934
		3	0.836	0.883	0.694	0.900	0.859	0.929
		Average	0.833	0.892	0.708	0.894	0.817	0.924
		95% CI	[0.821, 0.845]	[0.870, 0.913]	[0.628, 0.788]	[0.881, 0.907]	[0.722, 0.911]	[0.903, 0.945]
	Flair	1	0.770	0.782	0.669	0.855	0.755	0.866
		2	0.703	0.750	0.537	0.767	0.813	0.896
		3	0.753	0.752	0.640	0.852	0.673	0.869
		Average	0.742	0.761	0.615	0.825	0.747	0.877
		95% CI	[0.686, 0.798]	[0.733, 0.790]	[0.504, 0.726]	[0.745, 0.905]	[0.634, 0.860]	[0.851, 0.903]

ACC, accuracy; SEN, sensitivity; SPE, specificity; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval; Bold Value, average value of 3 folds.