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. 2022 Feb 24;13:828581. doi: 10.3389/fendo.2022.828581

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Copyright © 2022 Liu, Liu, Liu, Xin, Lyu and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spline graphical representation of the relationship between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and incident T2DM in the multivariable-adjusted model (model II). The restricted cubic splines showed a dose–response relationship between TG/HDL-C ratio variability and incident diabetes. With the increase of TG/HDL-C ratio, the hazard ratio (HR) of incident T2DM gradually increased and showed a curvilinear correlation.