Table 2.
The clinical and laboratory characteristics of term newborns with positive screening results (n=21)
| Newborn ID/Sex | ACTB/TREC/KREC |
Lymphocyte and its subgroups, /mm3 (Normal range**)
|
The other findings | |||||
|---|---|---|---|---|---|---|---|---|
| Age, in month/Lymphocyte | CD3+ | CD4+ | CD19+ | CD19+ CD27+ | CD56+ | |||
| 116/F* | 2360/2/9 | 36/2900 | 1006 | 693 | 272 | 19 | 27 | Late neonatal sepsis, Low IgG and IgM |
| (1400-3700) | (700-2200) | (390-1400) | (45-175) | (130-720) | ||||
| 163/M* | 1188/3/6 | 36/2400 | 900 | 478 | 365 | 30 | 70 | HFID, Normal immunoglobulins, Epilepsy, |
| (1400-3700) | (700-2200) | (390-1400) | (45-175) | (130-720) | Cerebral palsy. | |||
| 219/F | 3224/6/17 | 28/3027 | 2209 | 1422 | 544 | 90 | 211 | Normal immunoglobulins |
| (1400-3700) | (700-2200) | (390-1400) | (45-175) | (130-720) | ||||
| 246/M* | 1747/5/20 | 17/2899 | 1623 | 1188 | 1014 | 28 | 115 | Late neonatal sepsis, IgG, IgA |
| (2100-6200) | (1300-3400) | (720-2600) | (25-217) | (180-920) | ||||
| 248/M | 3167/24/6 | 35/4282 | 2997 | 1926 | 856 | 51 | 299 | HFID, Epilepsy, Cerebral palsy, Normal |
| (1400-3700) | (700-2200) | (390-1400) | (45-175) | (130-720) | immunoglobulins, Mutation in NFKB2 gene | |||
| 480/M | 1435/4/5 | 34/2748 | 1758 | 961 | 687 | 27 | 164 | No HFID, Normal immunoglobulins, Epilepsy |
| (1400-3700) | (700-2200) | (390-1400) | (45-175) | (130-720) | ||||
| 590/M | 2678/6/48 | N/A | N/A | N/A | N/A | N/A | N/A | Maternal diabetes mellitus |
| 686/M | 1901/4/58 | 36/3220 | N/A | N/A | N/A | N/A | N/A | No HFID, Low IgG, IgM and IgA |
| 719/M | 1895/16/3 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 749/M | 3932/4/28 | 1/3720 | N/A | N/A | N/A | N/A | N/A | N/A |
| 874/F | 1236/3/1 | 6/5200 | 3900 | 3068 | 1144 | 260 | 156 | No HFID, Normal immunoglobulins |
| (1900-5900) | (1400-4300) | (610-2600) | (25-217) | (160-950) | ||||
| 1181/M | 3475/5/19 | N/A | N/A | N/A | N/A | N/A | N/A | Developmental retardation, lymphadenopathy |
| 1184/M | 2124/4/15 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 1202/F | 3055/3/8 | N/A | N/A | N/A | N/A | N/A | N/A | Dysmorphism, trigonocephaly |
| 1208/F | 1637/3/25 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 1228/M | 1502/5/20 | N/A | N/A | N/A | N/A | N/A | N/A | Normal immunoglobulins, midgut volvulus |
| 1230/M | 2467/4/24 | N/A | N/A | N/A | N/A | N/A | N/A | Normal immunoglobulins, microcephaly, eczemaa |
| 1234/M | 2261/3/17 | N/A | N/A | N/A | N/A | N/A | N/A | Transient neutropenia |
| 1269/F | 3064/5/5 | N/A | N/A | N/A | N/A | N/A | N/A | Hearing loss |
| 1299/M | 1075/3/33 | N/A | N/A | N/A | N/A | N/A | N/A | Neutropenia, eczema |
| 1313/M | 1664/6/22 | 1/2390 | N/A | N/A | N/A | N/A | N/A | Anal atresia |
* Newborns with low T-cells and B-cells according to analysis of flow cytometry and their lymphocytes subsets are in bold; ** Age-matched normal values for lymphocyte subgroups are taken from two references (Shearer WT et al. Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol. 2003;112(5):973-980. Duchamp M et al. B-cell subpopulations in children: National reference values. Immun Inflamm Dis. 2014;2(3):131-140); M: Male, F: Female, IgG: Immunoglobulin G, IgA: Immunoglobulin A, IgM: Immunoglobulin M, ACTB: Actin-beta, TRECs: T-cell receptor excision circles, KRECs: κ-deleting recombination excision circles, HFID: History of frequent infection disease, NFKB2: Nuclear factor kappa B2, N/A: Not available.