Table 1.
Differentially accumulated amino acid, organic acid, and vitamin compounds with VIP ≥ 1, value of p < 0.05, and Log2FC ≥ 4 (upregulation) or ≤ −4 (downregulation) in TR vs. MG.
| Component name | Metabolite name | Average content | VIP | Value of p | Log2FC | Type | |
|---|---|---|---|---|---|---|---|
| MG | TR | ||||||
| Amino acid and derivatives | Glutathione reduced form | n.d. | 4.06E+06 | 1.17E+00 | 1.89E-03 | 1.88E+01 | up |
| O-phospho-L-serine | n.d. | 5.68E+04 | 1.17E+00 | 4.11E-02 | 1.26E+01 | up | |
| γ-glu-cys | n.d. | 2.25E+04 | 1.17E+00 | 3.20E-04 | 1.13E+01 | up | |
| Hexanoyl-L-glycine | n.d. | 1.81E+04 | 1.17E+00 | 4.55E-02 | 1.10E+01 | up | |
| L-arginine | 1.35E+07 | 2.28E+05 | 1.16E+00 | 1.46E-02 | −5.89E+00 | down | |
| N-α-acetyl-L-ornithine | 3.28E+06 | 3.43E+04 | 1.17E+00 | 6.78E-04 | -6.58E+00 | down | |
| Organic acids and derivatives | DL-glyceraldehyde-3-phosphate | n.d. | 5.56E+05 | 1.17E+00 | 7.05E-03 | 1.59E+01 | up |
| Malonic acid | n.d. | 3.67E+05 | 1.17E+00 | 8.97E-04 | 1.53E+01 | up | |
| 6-Hydroxyhexanoic acid | n.d. | 2.44E+05 | 1.17E+00 | 2.62E-02 | 1.47E+01 | up | |
| Phosphoenolpyruvate | n.d. | 2.20E+05 | 1.17E+00 | 2.23E-03 | 1.46E+01 | up | |
| 4,5,6-Trihydroxy-2-oxohexanoic acid | n.d. | 5.85E+04 | 1.17E+00 | 5.78E-03 | 1.27E+01 | up | |
| Tartronate semialdehyde | n.d. | 2.76E+04 | 1.17E+00 | 5.54E-03 | 1.16E+01 | up | |
| 2-Hydroxy-2-methylbutyric acid | n.d. | 1.01E+04 | 1.17E+00 | 5.78E-03 | 1.01E+01 | up | |
| 2-Hydroxyisocaproic acid | 8.63E+03 | 9.81E+05 | 1.01E+00 | 1.50E-02 | 6.83E+00 | up | |
| 3-Hydroxybutyric acid | 6.82E+04 | 4.94E+06 | 1.17E+00 | 1.23E-02 | 6.18E+00 | up | |
| 2-Hydroxyisobutyric acid | 8.17E+03 | 1.59E+05 | 1.17E+00 | 9.27E-03 | 4.28E+00 | up | |
| 4,8-Dihydroxyquinoline-2-carboxylic acid | 6.28E+04 | n.d. | 1.17E+00 | 1.33E-02 | -1.28E+01 | down | |
| Saccharides and alcohols | 3-Phospho-D-glyceric acid | n.d. | 7.84E+06 | 1.17E+00 | 2.99E-03 | 1.97E+01 | up |
| D-glucuronic acid | n.d. | 7.74E+05 | 1.17E+00 | 6.20E-03 | 1.64E+01 | up | |
| D-fructose-1,6-biphosphate | n.d. | 2.53E+05 | 1.17E+00 | 2.19E-02 | 1.48E+01 | up | |
| Nystose | 3.16E+04 | n.d. | 1.17E+00 | 1.40E-02 | -1.18E+01 | down | |
n.d., not detectable.