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(A) FIPV Mpro exists as a dimer when bound with the feline drug GC373 (PDB: 7SNA). Domains I, II, and III are labeled on the left. Active sites of both protomers are occupied by GC373. (B) The prodrug, GC376, is a dipeptidyl aldehyde bisulfite adduct that readily converts into GC373 under aqueous conditions. GC373 covalently binds to the catalytic Cys144 of FIPV Mpro.
