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. 2022 Feb 24;10:852210. doi: 10.3389/fchem.2022.852210

FIGURE 3.

FIGURE 3

Comparing Mpro N-terminal fingers and their respective interaction with GC373. (A) In FIPV Mpro (PDB: 7SNA), Ser1 of the N-terminal finger from protomer B forms a weak H-bond (3.8 Å) with the cyclic glutamine analog nitrogen of GC373, as well as other H-bonds with E165 and F139 in the active site of protomer A. (B) In SARS-CoV-2 Mpro (PDB: 6WTK), Ser1 of the N-terminal finger from protomer B only forms H-bonds with E166 and F140 in the active site of protomer A but does not form H-bonds with GC373.