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Doubly modified derivatives of GC376 at the P2 and P3 positions and their corresponding IC50 values. Data are presented as mean ± SEM, n = 3.
| Entry | Structure | FIPV Mpro IC50 (µM) | SARS-CoV-2 Mpro IC50 (µM) a |
|---|---|---|---|
| GC376 |
|
0.13 ± 0.02 | 0.19 ± 0.04 |
| 2c |
|
0.03 ± 0.01 | 0.07 ± 0.01 |
| 2d |
|
0.05 ± 0.02 | 0.08 ± 0.02 |
| 2e |
|
0.06 ± 0.02 | 0.04 ± 0.01 |
Data from Vuong et al. (2021).
