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Binding Affinities of Mitragynine (1) and its Diastereomers at Human Opioid Receptor (Obeng et al., 2021).
| Compound | Ki ± SEM (µM) a | ||
|---|---|---|---|
| hMOR (µ) | hKOR (κ) | hDOR (δ) | |
| Mitragynine (1) | 0.233 ± 0.048 | 0.772 ± 0.207 | >10 |
| Speciogynine (2) | 0.728 ± 0.061 | 3.200 ± 0.360 | >10 |
| Speciociliatine (3) | 0.560 ± 0.168 | 0.329 ± 0.112 | >10 |
All data points present mean ± SEM (µM) of n ≥ 3.
