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Screening of mitragynine (1) and speciociliatine (3) at opioid receptor (Obeng et al., 2020).
| Binding site | Percent displacement of bound radioligand | |||
|---|---|---|---|---|
| Mitragynine (1) | Speciociliatine (3) | |||
| 100 nM | 10,000 nM | 100 nM | 10,000 nM | |
| MOR | 29.0 | 93.7 | 64.7 | 98.0 |
| KOR | 25.2 | 88.3 | 61.9 | 98.5 |
| DOR | 0.4 | 18.3 | 0.6 | 69.2 |
| Nociceptin/Orphanin FQ peptide (NOP) | 4.3 | 40.8 | −14.9 | 31.8 |
