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Binding affinities of mitragynine (1) and speciociliatine (3) to opioid receptor and subtype selectivity (Obeng et al., 2020).
| Compound | DOP Ki ± SEM (nM) | KOP Ki ± SEM (nM) | MOP Ki ± SEM (nM) |
|---|---|---|---|
| DAMGO | ND | ND | 0.41 ± 0.04 |
| DPDPE | 1.32 ± 0.004 | ND | ND |
| U50488 | ND | 0.300 ± 0.002 | ND |
| Mitragynine (1) | ND | 198 ± 30 | 161 ± 10 |
| Speciociliatine (3) | ND | 116 ± 36 | 54.5 ± 4.4 |
