Fig. 4.

Carotid-femoral pulse wave velocity (cfPWV, Panels A and B) and aortic augmentation index (C, D) corrected for heart rate (AIX@75) in the BNT162b2 mRNA COVID-19 (1st and 2nd dose) and sham sessions during the study (mean and standard error of measurement). Values, where no time interaction was observed, are adjusted means from ANCOVA (fixed effects included time and baseline value was the covariate), while when time interaction was observed, adjusted mean values from ANCOVA (fixed effects included treatment and sequence and baseline value was the covariate) per time point were used. The latter model was used for estimating the mean difference. CI Confidence interval