Table 1.

In vitro studies on efficacy of NHC (Active component of Molnupiravir) against highly pathogenic Coronaviruses (MHV-A59, MERS-CoV, SARS-CoV, and SARS-CoV-2)

S. no.	Drug molecule	Cell line	Virus	IC50 & EC 50	References
1.	EIDD-1931	Murine astrocytoma delayed brain tumor cells	Coronavirus MHV-A59	EC50 = 0.17 μM	Agostini et al. (2019)
2.	EIDD-1931	Vero cells	MERS-CoV	EC50 = 0.56 μM	Agostini et al. (2019)
3.	EIDD-1931	Calu-3 2B4	MERS-CoV	IC50 of 0.15 μM	Sheahan et al. (2020)
4.	EIDD-1931	Vero E6 Cells	SARS-CoV-2	IC50 of 0.3 μM	Sheahan et al. (2020)
5.	EIDD-1931	Calu-3	SARS-CoV-2	IC50 of 0.09 μM	Sheahan et al. (2020)
6.	EIDD-1931	HAE	SARS-CoV-2		Sheahan et al. (2020)
7.	EIDD-1931	HAE	MERS-CoV	IC50 = 0.024 μM	Sheahan et al. (2020)
8.	EIDD-1931	HAE	SARS-CoV	IC50 = 0.14 μM	Sheahan et al. (2020)
9.	EIDD-2801	Calu-3	SARS-CoV-2	IC50 = 414.6 nM	Rosenke et al. (2021)

Coronavirus MHV-A59: coronavirus murine hepatitis virus A-59; Vero E6: African green monkey kidney epithelial cells; MERS-CoV: Middle East respiratory syndrome-related coronavirus; Calu-3: human bronchial epithelial cells; SARS-CoV-2: The virus, severe acute respiratory syndrome coronavirus 2; HAE: human airway epithelial cells; SARS-CoV: severe acute respiratory syndrome-related coronavirus