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. 2022 Feb 24;9:842024. doi: 10.3389/fmed.2022.842024

Figure 1.

Figure 1

Schematic diagram of the aging-related changes in the liver. During the aging process of the liver, a series of alterations was observed in genes, proteins and metabolites. The oxidative homeostasis was disrupted, thus lead to oxidative stress. During aging, the number of polyploid, senescent, and apoptotic hepatocytes increased. Hepatic stellate cells in the aged liver contained more lipid droplets and released less growth factors than those in the young liver. The defenestration liver sinusoid endothelial cells occurred during aging, and thus disrupted the substance exchange, such as insulin and growth factors. Moreover, more extracellular matrix was deposited in Disse space in the aged liver.