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. 1999 Feb;43(2):367–370. doi: 10.1128/aac.43.2.367

TABLE 2.

Substitutions in blaTEM genes and derived penicillinases and extended-spectrum β-lactamases

Region and nucleotide no.a (amino acid no.b) Nucleotide (amino acid) in the following gene (enzyme):
blaTEM-1a (TEM-1 [Tn3]) blaTEM-1b (TEM-1 [Tn2]) blaTEM-2 (TEM-2 [Tn1]) blaTEM-1c (TEM-1) blaTEM-8 (TEM-8) blaTEM-10b (TEM-10)
Promoter region P3 P3 Pa and Pb P3 Pa and Pb Pa and Pb
 32 C C T C T T
 147 T T T T A T
 162 G G G G G G
 175 A G A A A G
Coding region
 226d C (Phe) T C C C T
 263 (21) C (Leu)21 C C C C C
 317 (39) C (Gln)39 C (Gln)39 A (Lys)39 C (Gln)39 A (Lys)39 C (Gln)39
 346d A (Glu) A G A G A
 436d C (Gly) T T T T T
 512 (104) G (Glu)104 G G G A (Lys)104 G
 604d G (Ala) T G G G T
 682d T (Thr) T C T C T
 692 (164) C (Arg)164 C C C A (Ser)164 A (Ser)164
 693 (164) G (Arg)164 G G G G G
 911 (237) G (Ala)237 G G G G G
 914 (238) G (Gly)238 G G G A (Ser)238 G
 917 (240) G (Glu)240 G G G G A (Lys)240
 925d G (Gly) G A G A G
 990 (265) C (Thr)265 C C C C C
Nucleotide (amino acid) in the following gene (enzyme):
blaTEM-11 (TEM-11) blaTEM-12c (TEM-12) blaTEM-13 (TEM-13) blaTEM-15a (TEM-15) blaTEM-15b (TEM-15) blaTEM-24b (TEM-24) blaTEM-53 (TEM-53)
Pa and Pb Pa and Pb or P3 P3 P4 Pa and Pb Pa and Pb Pa and Pb
T T/Cc C C T T T
T T T T T A T
G G G T G G G
A G A A G A A
C T C C T C C
C C C C C C T (Phe)21
A (Lys)39 C (Gln)39 A (Lys)39 C (Gln)39 C (Gln)39 A (Lys)39 C (Gln)39
G A G A A G G
T T T C T T T
G G G A (Lys)104 A (Lys)104 A (Lys)104 G
G T G G T G G
C T C T T C C
C A (Ser)164 C C C A (Ser)164 A (Ser)164
A (His)164 G G G G G G
G G G G G A (Thr)237 G
G G G A (Ser)238 A (Ser)238 G G
G G G G G A (Lys)240 G
G G A G G G A
C C T (Met)265 C C C C
a

Numbering is according to Sutcliffe (25). 

b

Numbering is according to Ambler et al. (1). 

c

Position 32 is T for blaTEM-12c from E. coli F1 (26) and C for blaTEM-12c from E. coli MG32 (28). 

d

Position at which only silent mutations occur.