TABLE 3.
Substitutions in blaTEM genes and derived inhibitor-resistant β-lactamases
| Region and nucleotide no.a (amino acid no.b) | Nucleotide (amino acid) in the following gene (enzyme):
|
|||||
|---|---|---|---|---|---|---|
| blaTEM-1a (TEM-1 [Tn3]) | blaTEM-1b (TEM-1 [Tn2]) | blaTEM-2 (TEM-2 [Tn1]) | blaTEM-33b (TEM-33) | blaTEM-33c (TEM-33) | blaTEM-54 (TEM-54) | |
| Promoter region | P3 | P3 | Pa and Pb | Pa and Pb | P4 | Pa and Pb |
| 32 | C | C | T | T | C | T |
| 162 | G | G | G | G | T | G |
| 175 | A | G | A | G | A | A |
| Coding region | ||||||
| 226c | C (Phe) | T | C | T | C | C |
| 317 (39) | C (Gln)39 | C (Gln)39 | A (Lys)39 | C (Gln)39 | C (Gln)39 | C (Gln)39 |
| 346c | A (Glu) | A | G | A | G | A |
| 407 (69) | A (Met)69 | A | A | C (Leu)69 | C (Leu)69 | A |
| 436c | C (Gly) | T | T | T | T | C |
| 604c | G (Ala) | T | G | T | G | G |
| 682c | T (Thr) | T | C | T | C | T |
| 925c | G (Gly) | G | A | G | A | G |
| 929 (244) | C (Arg)244 | C | C | C | C | C |
| 930 (244) | G (Arg)244 | G | G | G | G | T (Leu)244 |
| 1022 (276) | A (Asn)276 | A | A | A | A | A |