Table 2.
Demographics, clinical characteristics and patient-reported outcome measures (PROs) among adolescents with juvenile fibromyalgia syndrome.
|
All subjects
(n = 31) |
(+) Subjective
dyscognition (n = 20) |
(-) Subjective
dyscognition (n = 11) |
P-value | |
|---|---|---|---|---|
| Demographics | ||||
| Age (median, IQR) | 15 (14-16) | 15 (14-16) | 15 (13-16) | 0.90 |
| Female, n (%) | 27 (87%) | 17 (63%) | 10 (37%) | 0.40 |
| White, n (%) | 25 (81%) | 16 (64%) | 9 (36%) | 0.31 |
| Non-hispanic, n (%) | 28 (90%) | 18 (64%) | 10 (36%) | 0.46 |
| Clinical characteristics, median, IQR | ||||
| Pain duration (months) | 12 (6-36) | 21 (12-36) | 10 (5-60) | 0.44 |
| Pain visual analog scale (VAS) (0-100) | 59 (32-68) | 60 (52.5-67.5) | 52 (16-68) | 0.23 |
| Widespread pain index (WPI) (0-19) | 11 (9-13) | 11 (8.5-13) | 12 (9-14) | 0.54 |
| Symptom severity score (SSS) (0-12) | 8 (7-9) | 9 (7-9.5) | 7 (5-9) | 0.05 |
| Patient-reported outcome measures (PROs), median (IQR) | ||||
| Functional disability inventory (FDI) (0-60) | 23 (15-31) | 25.5 (17-33) | 16 (10-26) | 0.02I |
| HRQOL [PROMIS global health 7 (PGH-7)] | 38.8 (30.8-40.4) | 36.4 (30-38.8) | 40.4 (38.8-45.7) | 0.01I |
| 14-item resilience scale (14-98) | 72 (59-81) | 66 (53-75) | 76 (72-86) | 0.02I |
| CDI-2 (depression) | 64 (51-72) | 67 (55-76) | 55 (47-59) | 0.02I |
| MASC-2 (Anxiety) | 65 (52-80) | 70 (63.5-82) | 52 (49-62) | 0.01I |
| PedsQL general fatigue | 33 (25-50) | 25 (19-37.5) | 50 (42-63) | <0.01I |
| PedsQL sleep/rest fatigue | 42 (25-54) | 40 (25-46) | 54 (29-63) | 0.06 |
Significant p-values suggesting statistical significance.
For subjective dyscognition, 20 subjects were positive on the PedsQL (Pediatric Quality of Life Inventory) Cognitive Functioning Scale only and eight subjects were positive on the BRIEF-2 GEC and PedsQL Cognitive Functioning Scale. IQR, interquartile range; Pain VAS, Pain visual analog scale where higher scores indicate more pain; SSS, Symptom Severity Scale, higher scores indicating greater symptom severity; WPI, widespread pain index, higher values indicating greater involvement of different anatomical regions where the child has experienced pain over the past 7 days; FDI, Functional disability inventory, greater scores indicating more functional disability; HRQoL, Health Related Quality of Life assessed using the PROMIS Pediatric Global Health 7 (PROMIS PGH-7). 14-item Resilience Scale ranges from 14 to 98, with greater scores indicating greater resilience. CDI-2, The Children's Depression Inventory, 2nd Edition where higher score (T-score ≥ 65) indicative of clinical depression. MASC-2, Multidimensional Anxiety Scale for Children, 2nd Edition, higher score (T-scores ≥ 60) indicate increased likelihood of at least one anxiety disorder in the subject. PedsQL (The Pediatric Quality of Life Inventory) General Fatigue and Sleep/Rest Fatigue scales are scored 0-100, where higher scores indicate less symptoms/problems in a dimension.