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. 2022 Feb 24;13:821166. doi: 10.3389/fneur.2022.821166

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Copyright © 2022 Petro, Agarkova, Esmael, Dunigan, Van Etten and Pattee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sera from ALS patients (n = 18) and healthy control subjects (n = 13) were analyzed by IgG subclass (IgG1, IgG2, IgG3, IgG4) for reactivity to ATCV-1 virus-coated ELISA plates. Data were analyzed for statistical significance using Student's t-test with the GraphPad Prism software. Significance is p < 0.05.