Figure 3.

(A) SOD1-G93A-transgenic mice and control wild-type (wt) C57Bl/6 mice were inoculated i.c. with 5 x 10⁸ PFU of ATCV-1 (n = 9; 50 μl) or PBS (n = 9; 50 μl) at 35 days of age. (B) A second cohort of SOD1G93A transgenic mice were inoculated i.c with PBS (n = 5) or 5 x 10⁸ heat-killed (HK) ATCV-1 (n = 5). (C) A third cohort of SOD1G93A transgenic mice were inoculated i.c with PBS (n = 10) or poly I:C(20 μg) (n = 20). Latency (sec) to fall of inoculated transgenic or wt mice after hanging from an cage lid (data analyzed by 2-way ANOVA using GraphPad Prism software).